Interleukin-17 inhibits development of malignant pleural effusion via interleukin-9-dependent mechanism
نویسندگان
چکیده
منابع مشابه
Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism.
Interleukin 17 (IL-17) is a proinflammatory cytokine produced by activated CD4(+) memory T cells. We previously showed that IL-17 increased the growth rate of human cervical tumors transplanted into athymic nude mice. To address the possible role of T cells in the biologic activity of IL-17 for tumor control, we grafted 2 murine hematopoietic immunogenic tumors (P815 and J558L) transfected with...
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Interleukin (IL)-1 is a key cytokine in inflammatory reactions. To clarify the mechanism of inflammation in the pleural cavity, we investigated the contribution of IL-1 and its antagonism to inflammatory processes in the pleural cavity. Interleukin-1 receptor antagonist (IL-1Ra) levels as well as IL-1 beta and interferon-gamma (IFN-gamma) levels were measured by enzyme immunoassay in pleural ef...
متن کاملMalignant pleural effusion.
Malignant pleural effusion (MPE) refers to the presence of neoplastic cells in the pleural fluid. Approximately 40 000 people per year in the UK are affected by MPE and it is associated with significant morbidity and an overall poor prognosis. Management should be prompt and care plans should be individualized and involve a multidisciplinary team of healthcare professionals. This article review...
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Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in t...
متن کاملMalignant pleural effusion.
Kathleen Shuey, MS, RN, AOCN®, APRN, BC, is an associate director at US Oncology in Houston, TX, and Yvette Payne, MSN, MBA, RN, APN, is an associate director of Clinical Affairs–Oncology at Ortho Biotech Clinical Affairs, LLC, in Tampa, FL. (Mention of specifi c products and opinions related to those products do not indicate or imply endorsement by the Clinical Journal of Oncology Nursing or t...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2016
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-016-0097-y